Abstract
One of the significant challenges for automated patch clamp has been to incorporate amplifiers with the ability of adjusting to changes in membrane capacitance, series resistance (Rs) and voltage-clamp time constants without user intervention. If these adjustments are not made correctly there is a risk of generating un-precise data or even losing data due to oscillations in the recorded trace. Rs compensation capability of the patch clamp amplifier of QPatch is presented. A new “clip detector feature” allowing Rs to be temporarily turned off avoiding loss of cells due to fatal oscillations, and thereby increasing the data throughput while maintaining high quality recordings, is presented.
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