Abstract
Mantle cell lymphoma is a rare lymphoma and involvement of bone marrow is more rare. Here, we concluded the features, diagnosis and other points of the involvement to illustrate the diagnostic main point of mantle cell lymphoma on pathology. Objective To explore clinicopathological features, diagnosis and differential diagnosis of bone marrow involvement of mantle cell lymphoma (MCL). Methods 55bone marrowinvolvementofMCLwith bone marrow biopsy from 2006to2012 were analyzed retrospectively.There were 15 patients with lymph node specimens and available 8 spleen specimens in the 55 patients. We found some features of bone marrow involvement of MCL on the basis of WHO classification. Results The median age at diagnosis is 55 years, M:F = 2.67:1 (male 40 and female 15). The type of involvement includes interstitial, intrasinusoidal, diffuse and mixed infiltration; the last is common. MCL usually consists of small to medium-sized lymphoid elements and characterized by expression of the B-cell markers. The characteristic expression of MCL is CD5 and cyclinD1. The MCL has four cytological variants. Among these, the classic variant is most commonly found. The prognosis has two major factors, the number of mitotic figures and Ki-67 making can divide different groups on prognosis. Conclusion The infiltration of MCL is rare and has specific features on bone marrow. It must be distinguished from other mature B cell lymphomas.
Published Version
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