Abstract
BackgroundThe objectives of this study are to investigate the clinicopathological characteristics and prognosis analysis of unicentric retroperitoneal Castleman’s disease (CD), and to improve the level of diagnosis and treatment of unicentric retroperitoneal CD.MethodsThe clinical data of 14 patients with unicentric retroperitoneal CD undergoing surgery from September 2007 to March 2014 were retrospectively reviewed.ResultsThere were six males and eight females with a median age of 39 years old (range 15–58). Only three patients had a clinical manifestation of abdominal pain, and one patient associated with myasthenia gravis. All patients underwent surgical resection. The mean operation time was 137 min with a range of 72–472 min. The mean blood loss was 143 ml (range 50–500 ml). The CD was confirmed by histopathology. There were hyaline vascular (HV) type of CD in 13 cases, and mixed type of CD in one case. The mean hospital stay was 17.9 days with a mean postoperation hospital stay of 9.2 days. The duration of follow-up ranged from 21 to 99 months for 14 cases. All the 14 patients were alive without recurrence.ConclusionsUnicentric retroperitoneal CD is a rare disease that is often misdiagnosed due to the absence of specific clinical manifestations. The final diagnosis depends on pathologic examination. Complete surgical resection of the tumor is the best therapeutic alternative for unicentric CD.
Highlights
The objectives of this study are to investigate the clinicopathological characteristics and prognosis analysis of unicentric retroperitoneal Castleman’s disease (CD), and to improve the level of diagnosis and treatment of unicentric retroperitoneal CD
Three patients had a clinical manifestation of abdominal pain or uncomfortable, and one patient associated with myasthenia gravis
The diagnosis of CD was confirmed after the resection and histological examination of the specimen
Summary
The objectives of this study are to investigate the clinicopathological characteristics and prognosis analysis of unicentric retroperitoneal Castleman’s disease (CD), and to improve the level of diagnosis and treatment of unicentric retroperitoneal CD. Castleman’s disease (CD) was first described in 1956 by Benjamin Castleman, who identified a series of patients with solitary hyperplastic mediastinal lymph nodes containing small, hyalinized follicles, and marked interfollicular vascular proliferation [1]. Two clinical types (unicentric and multicentric) have been subclassified on histological forms: hyaline vascular (HV) type, plasma cell (PC) type, and mixed type. As this disease is rare and poorly understood, the optimal therapy is unknown. This study was conducted to analyze the
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