Abstract
BackgroundSalivary gland tumors are rare salivary gland malignancies with resemblance to ductal breast carcinoma. We have described clinicopathological behavior and treatment outcomes of this rare malignancy.MethodsSalivary duct carcinoma patients treated from 2010 to 2015 were retrospectively analyzed for clinicopathological characteristics and treatment-related outcomes of the disease.ResultsA total of 12 patients with salivary duct carcinoma were included in the study. All were males with mean age of 52.58 ± 13.43. Parotid gland was the most commonly involved major salivary gland while buccal mucosa and anterior tongue were most common oral cavity sub-sites involving minor salivary glands. The disease-free survival was 75% at 10 months and 25% at 20 months. The mean follow-up time was 12 months. There were three local recurrences and one distant metastasis.ConclusionSalivary duct carcinoma is a locally aggressive tumor with tendency for local recurrence and distant metastasis. Adverse features such as perineural invasion, extra-capsular spread and advanced nodal disease may worsen prognosis.
Highlights
Salivary duct carcinomas are rare tumors representing 10% of salivary gland malignancies
A total of 12 patients with salivary duct carcinoma were included in the study
The histological features resemble to invasive ductal carcinoma of the breast and require immunohistochemistry to rule out metastasis among patients with previous history of breast carcinoma [1]
Summary
A total of 12 patients with salivary duct carcinoma were included in the study. All were males with mean age of 52.58 ± 13.43. Received 07/30/2018 Review began 08/05/2018 Review ended 08/10/2018 Published 08/14/2018
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