Abstract
ObjectiveThe prognostic significance of CD24 expression for survival in patients with gastric cancer remains controversial. We conducted a meta-analysis to investigate the impact of CD24 expression on clinicopathological features and survival outcomes in gastric cancer.MethodsA comprehensive literature search of the electronic databases PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI; up to April 8, 2014) was performed for relevant studies using multiple search strategies. Correlations between CD24 expression and clinicopathological features and overall survival (OS) were analyzed.ResultsA total of 1,041 patients with gastric cancer from 9 studies were included. The pooled odds ratios (ORs) indicated CD24 expression was associated with tumor depth (OR = 0.45, 95% confidence interval [CI] = 0.32–0.63; P<0.00001), status of lymph nodes (OR = 0.40, 95% CI = 0.25–0.64; P = 0.0001) and tumor node metastasis (TNM) stage (OR = 0.56, 95% CI = 0.41–0.77; P = 0.0003). The pooled hazard ratio (HR) for OS showed overexpression of CD24 reduced OS in gastric cancer (HR = 1.99, 95% CI = 1.29–3.07, P = 0.002). Whereas, combined ORs showed that CD24 expression had no correlation with tumor differentiation or Lauren classifications.ConclusionCD24 overexpression in patients with gastric cancer indicated worse survival outcomes and was associated with common clinicopathological poor prognostic factors.
Highlights
Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer-related death worldwide [1]
Studies meeting the following inclusion criteria were included: (1) CD24 expression was evaluated in the primary GC tissues; (2) CD24 expression was examined by immunohistochemistry (IHC); (3) studies revealed the relationship between CD24 expression and GC clinicopathological parameters or prognosis; (4) studies regarding the prognosis provided sufficient information to estimate hazard ratios (HRs) for overall survival (OS) and 95% confidenceintervals (CIs); (5) if there were multiple articles based on similar patients, only the largest or most recently published article was included
The correlation between CD24 expression and GC has been studied by a number of researchers
Summary
Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer-related death worldwide [1]. Having undergone radical resection and postoperative adjuvant therapy, most patients with GC will die of recurrence and metastasis. Several clinicopathological parameters such as tumor size, histological type, tumor differentiation, depth of tumor invasion, regional lymph node involvement, distant metastasis and tumor stage, have been reported as important prognostic factors for GC [2,3,4,5,6]. Several studies have shown that CD24 played important roles in the regulation of B-cell apoptosis, leukocyte signal transduction, leukocyte adhesion and cell selection or maturation during hematopoiesis [8,9,10, 14, 15]
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