Abstract
BackgroundThe aim of this study is to review all features of incidentally discovered prostate adenocarcinoma in patients undergoing radical cystoprostatectomy for bladder cancer.MethodsThe medical charts of 300 male patients who underwent radical cystoprostatectomy for bladder cancer between 1997 and 2005 were retrospectively reviewed. The mean age of the patients was 62 (range 51-75) years.ResultsProstate adenocarcinoma was present in 60 (20%) of 300 specimens. All were acinar adenocarcinoma. Of these, 40 (66.7%) were located in peripheral zone, 20 (33.3%) had pT2a tumor, 12 (20%) had pT2b tumor, 22(36.7%) had pT2c and, 6 (10%) had pT3a tumor. Gleason score was 6 or less in 48 (80%) patients. Surgical margins were negative in 54 (90%) patients, and tumor volume was less than 0.5 cc in 23 (38.3%) patients. Of the 60 incidentally detected cases of prostate adenocarcinoma 40 (66.7%) were considered clinically significant.ConclusionIncidentally detected prostate adenocarcinoma is frequently observed in radical cystoprostatectomy specimens. The majority are clinically significant.
Highlights
The aim of this study is to review all features of incidentally discovered prostate adenocarcinoma in patients undergoing radical cystoprostatectomy for bladder cancer
Prostate adenocarcinoma (PCa) is the most common visceral malignancy in the male population and the second leading cause of death in men [1]. It can be found incidentally when the prostate is removed during radical cystoprostatectomy (RCP) for bladder cancer and latently at autopsy or clinically diagnosed by physical examination, laboratory tests, and symptoms [2,3]
In autopsy series incidental prostate cancer is found in 30% of men in their fifth decade and that rate increases to as high as 90% in men aged older than 90 years [4]
Summary
The aim of this study is to review all features of incidentally discovered prostate adenocarcinoma in patients undergoing radical cystoprostatectomy for bladder cancer. Prostate adenocarcinoma (PCa) is the most common visceral malignancy in the male population and the second leading cause of death in men [1]. It can be found incidentally when the prostate is removed during radical cystoprostatectomy (RCP) for bladder cancer and latently at autopsy or clinically diagnosed by physical examination, laboratory tests, and symptoms [2,3]. The frequency of PCa incidentally discovered in RCP specimens is extremely variable, ranging from 10% to nearly 60% [1,3,5] These tumors are typically small, well- or moderately well-differentiated, localized entirely within the gland, and most being regarded as clinically insignificant [3,6].
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