Clinical-functional and nutritional-metabolic features of the comorbid phenotype of vibration disease in combination with arterial hypertension

Abstract

Introduction. Currently, the occupational etiological factors of vibration disease are well studied, but the management of this group of patients against the background of comorbid pathology, the impact on the quality of life of patients and the long-term prognosis of the disease remains an urgent problem.Aim. Study of nutritional and metabolic status in patients with vibration disease in combination with arterial hypertension.Materials and methods. A survey of 336 patients with vibration disease in combination with arterial hypertension was conducted in the conditions of the regional center of occupational pathology on the basis of a specialized department of occupational pathology. A comprehensive assessment of the clinical, nutritional and metabolic status of patients with vibration disease in combination with hypertension was carried out, including the study of clinical parameters, the daily profile of blood pressure, protein, lipid and carbohydrate metabolism, the component composition of the body of patients and the assessment of the profile of adipokines and cytokines.Results and discussion. Insufficient reduction of pressure at night (non-dippers) was revealed, an increase in fat mass and extracellular fluid was determined against the background of lean mass deficiency and a decrease in phase angle, proatherogenic dyslipidemia, protein deficiency, impaired carbohydrate metabolism, high levels of adipokine and cytokine activity.Conclusion. As a result of the study, additional markers for the diagnosis of nutritional disorders in the combined course of vibration disease and arterial.Conclusions. As an early diagnosis of nutritional and metabolic disorders in vibration disease in combination with arterial hypertension, the most informative integral indicators characterizing nutritional and metabolic disorders in this phenotype were identified – the waist circumference/hip circumference index and active cell mass.