Clinical values of SAA and hs-CRP in the diagnosis of postoperative infection in patients with ovarian tumor

Abstract

Objective To investigate the clinical values of serum amyloid A(SAA) and hypersensitivity C reactive protein(hs-CRP) in the diagnosis of postoperative infection in patients with ovarian tumor. Methods Clinical data of 679 patients with ovarian tumor were retrospectively analyzed.According to the development of postoperative infection or not, all patients were assigned into infection group(n=45) or non-infection group(n=634). The primary outcomes indicators were SAA, hs-CRP, C reactive protein(CRP) and white blood cell. Results Compared with the non-infection group, the infection group got a significantly higher levels of SAA[(104.73±34.74)mg/L vs.(6.12±0.74)mg/L, t=25.546, P=0.000]and hs-CRP[(142.35±43.84)mg/L vs.(18.45±5.39)mg/L, t=24.595, P=0.000]and white blood cell[(11.48±3.59)×109/L vs.(7.49±2.83)×109/L, t=6.305, P=0.000]and CRP[(32.58±10.48)mg/L vs.(16.34±8.47)mg/L, t=8.496, P=0.000]. The area under the Receiver Operating Characteristic of SAA, hs-CRP, white blood cell and CRP were 0.879(95% confidence interval: 0.825~0.920, P=0.000), 0.858(95% confidence interval: 0.792~0.925, P=0.000), 0.737(95% confidence interval: 0.658~0.817, P=0.000) and 0.767(95% confidence interval: 0.713~0.822, P=0.000). Z tests showed that the areas under the curve of SAA and hs-CRP in the diagnosis of postoperative infection in patients with ovarian tumor were higher than white blood cells and CRP(all P<0.05). Conclusion SAA and hs-CRP have better diagnostic values in the postoperative infection of ovarian tumor, and it is worth to be popularized. Key words: Ovarian neoplasms; Serum amyloid A protein; C-Reactive protein