Abstract
The indirect immunofluorescence method of Coons was applied for the detection of circulating antiglomerular and antinuclear autoantibodies in 100 cases of various renal diseases. The highest incidence of positive antiglomerular autoantibodies was observed in chronic glomerulonephritis and lupus nephritis. An analysis was made of the correlations of indirect immunofluorescence with the pathomorphological type and with the clinical manifestation and evolution in chronic glomerulonephritis. The highest incidence of positive antiglomerular autoantibodies was found in membranous glomerulonephritis and mixed membranous-proliferative glomerulonephritis. The presence of circulating autoantibodies was associated with more severe clinical conditions and evolution of the disease. In lupus nephritis, the occurrence of circulating antinuclear autoantibodies was a nearly regular event, parallel to, but more persistent than LE cell phenomenon in treated patients. The possible prognostic and therapeutic meaning of the results of indirect immunofluorescence in immune glomerular diseases is also discussed.
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