Clinical value of contrast-enhanced ultrasonic contrast in the diagnosis of thyroid microcarcinoma

Abstract

Objective To investigate the clinical value of contrast-enhanced ultrasonic contrast in the diagnosis of thyroid microcarcinoma. Methods A total of 115 patients with thyroid nodules diagnosed surgically and pathologically were selected. Chose a series of contrast pulse contrast imaging(CPS) features of Acuson sequoia 512 color Doppler ultrasound diagnostic apparatus and Italy Bracco company production of ultrasound contrast agent SonoVue, the patients received routine ultrasonography firstly, then received ultrasonic contrast. Results Of 115 nodules, 49 malignant nodules, including 49 cases of papillary thyroid carcinoma, 1 case of papillary carcinoma with metastasis; 66 benign nodules, including 54 cases of nodular goiter(3 cases with calcification), 7 cases of adenomas(1 case with calcification), left thyroid sub acute thyroiditis in 1 case, 4 cases with benign nodules.Benign nodules were more common than malignant nodules, the boundary was clearly more than the malignant nodules, low echo in less malignant nodules, the blood flow signal was less than that of malignant nodules(χ2=9.356, 9.144, 9.832, 6.581, all P<0.05). Benign nodules enhanced significantly more than the uniform malignant nodules, malignant nodules enhanced significantly less than the low, enhanced significantly more than the malignant clear boundary nodules(χ2=6.130, 5.791, 23.206, all P<0.05). The specificity, sensitivity and accuracy of contrast-enhanced ultrasound were higher than conventional ultrasound(χ2=6.971, 7.462, 7.152, all P<0.05). Conclusion Ultrasonic contrast has high clinical value in the diagnosis of thyroid microcarcinoma, and the sensitivity, specificity and accuracy are high, and can significantly improve the detection rate of thyroid microcarcinoma. Key words: Ultrasonography; Phlebography; Thyroid neoplasms