Abstract
BackgroundThe aim of this study was to evaluate whether serum cystatin C could serve as a predictor of multivessel coronary artery disease identified by coronary angiography in type 2 diabetes patients with normal renal function and to suggest the cutoff point of serum cystatin C for predicting multivessel disease.MethodsSerum cystatin C concentrations were measured by using particle-enhanced immunonephelometric assays before coronary angiography in 135 consecutive type 2 diabetes patients and 179 nondiabetic patients with normal renal function. Routine anthropometric and serologic data were collected. The severity of multivessel disease was assessed with the Gensini score after coronary angiography. The associations of serum cystatin C with the Gensini score were investigated, and the independent risk factors associated with multivessel disease were assessed.ResultsSerum cystatin C and the Gensini score were significantly elevated in diabetes patients. Cystatin C had a positive correlation with Gensini score. A multiple logistic regression analysis demonstrated that cystatin C was independently associated with the presence of multivessel disease (the OR score is 2.21, P = 0.003). Based on the ROC curve, a cystatin C level of 0.865 mg/L showed 67.7% sensitivity and 76.3% specificity with an AUC of 0.748 in diabetes patients for detecting multivessel disease.ConclusionSerum cystatin C is significantly correlated with the presence of multivessel disease, suggesting that cystatin C might be utilized as a screening tool for predicting multivessel disease in type 2 diabetes mellitus patients with normal renal function.
Highlights
Type 2 diabetes mellitus is common and an important cause of morbidity and mortality
Characteristics of individuals with and without diabetes Among the 135 diabetes and 179 nondiabetic patients who participated in this study, the uric acid (UA) and fasting plasma glucose (FPG) levels were significantly higher in patients with diabetes than in those without diabetes (P = 0.003, P
Our results indicate that diabetes patients had higher serum cystatin C levels than nondiabetic patients
Summary
Type 2 diabetes mellitus is common and an important cause of morbidity and mortality. Type 2 diabetes mellitus is associated with accelerated atherosclerotic processes affecting arteries that supply major organs in the. Multivessel disease is the most fatal and frequently observed coronary artery disease in type 2 diabetes patients. The close correlation between multivessel disease and fluctuating blood glucose levels in type 2 diabetes patients has been shown in clinical and experimental studies [6]. The detailed mechanisms underlying the link between multivessel disease identified by coronary angiography and type 2 diabetes mellitus remain to be elucidated. The aim of this study was to evaluate whether serum cystatin C could serve as a predictor of multivessel coronary artery disease identified by coronary angiography in type 2 diabetes patients with normal renal function and to suggest the cutoff point of serum cystatin C for predicting multivessel disease
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