Abstract
Background: The role of perinuclear antineutrophil cytoplasmic antibodies (pANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA) assessment in inflammatory bowel disease (IBD) diagnosis and differentiating is still imprecise and controversial. Methods: The aim of the study was to determine the accuracy of pANCA and ASCA in patients with specific intestinal inflammations, namely UC, CD, GI Behcet (GI-BD), GI tuberculosis (GI-TBC) which are under the same inflammatory bowel registry, compared to tree control groups; namely, Celiac disease, irritable bowel syndrome (IBS) patients and healthy controls (HC). A total of 493 subjects (102 with UC, 63 with CD, 13 with GI BD, 10 with GI Tb, 130 with IBS, 10 with Celiac disease, and 165 HC) firstly admitted to our weekly IBD outpatient practice of a tertiary referral center were analyzed regarding pANCA and ASCA Ig A-G via immunofluorescent assay (IFA) with commercially available IFA kits (Euroimmune, Lübeck, Germany). Results: The prevalence of any pANCA or ASCA positivity and age and sex of patients are summarized in Table 1. In UC patients the prevalence of pANCA was 42.2%, which was significantly higher than in CD-4.8% (p = 0.000). ASCA was found significantly more often in CD-54% than in UC patients-4.8% (p = 0.000). The prevalence of ASCA in BD patients-15.4% disclosed a significant difference compared to CD patients (p = 0.014), but the prevalence of ASCA in TBC patients showed no significant difference compared to CD or BD patients. Table 1: Prevalence of pANCA and ASCA in different subgroups.Marked values(p < .05)Tabled 1pANCA(+)ASCA(+)agemale(%)IBS (n = 130)1(0.8%)4(3.07%)40.84(SD 12.69)*42.3(a)HC (n = 165)1(0.6%)7(4.2%)35.07(SD 10.49)*;**40(b)UC (n = 102)43 (42.2%)11(10.8%)40.72(SD 13.44)**50(c)CD (n = 63)3 (4.8%)34(54%)37.56(SD 12.65)38.1(d)GI-BD (n = 13)02(15.4%)32.11(SD 8.89)61(e)Celiac Disease (n = 10)04(40%)36.77(SD 7.94)0(a;b;c;d;e;f)GI-TBC (n = 10)1(10%)3(30%)(SD 9.96)70(f) Open table in a new tab Conclusion: Our results confirm that in clinical practice ASCA is not specific enough to be a useful tool in differential diagnosis of any specific inflammation. However, it may have some value in screening of normal population for any bowel inflammation. pANCA may have a better clinical value in the discrimination of UC from other intestinal inflammations. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive
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