Abstract
Abstract Peripheral blood or bone marrow lymphoid cells from 81 cases of chronic lymphocytic leukemia (CLL) and from 34 children and 31 adults with acute lymphocytic leukemia (ALL), were evaluated for surface immunoglobulin (sIg), cytoplasmic immunoblobulin (cIg) and with anti-la and anti-pan T-cell (T101) monoclonal antibodies (MoAbs). In childhood ALL, the majority of cases (65%) were Ia + T101 - cIg - sIg - . Anti-Ia and T101 reactivity were mutually exclusive and the Ia + T101 - phenotype was associated with better prognostic factors and longer median disease free survival than the Ia - Tl01 + phenotype. In adult ALL, the majority of cases (65%) were also Ia + T101 - cIg - sIg - . Anti-Ia and T101 reactivity were not mutually exclusive, however, all T101 + patients presented with leukemic cell counts greater than 75, 000/mm 3 . In CLL, all cases were Ia + , and the most common phenotype was Ia + T101 + sIg + . Paraproteinemia was present in 8/9 cases with the Ia + T101 - sIg + phenotype and proteinuria was found in 3/5 patients with the E-rosette negative, Ia + T101 + sIg - phenotype. The data suggests that these MoAbs may be useful in identifying clinically relevant subgroups of acute and chronic lymphocytic leukemia.
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