Abstract
Human Vα24+Vβ11+ invariant NKT (iNKT) cells are distinct lymphocytes that play an important role in tumor immunity. iNKT cells have the capability to positively modulate the function of a wide variety of immune cells in both direct and indirect manner, thereby bridging innate and acquired immunity. Abnormalities in the number and function of iNKT cells have been observed in patients with malignant diseases, and their presence is associated with a poor clinical outcome. Therefore, therapeutic strategies focused on the reconstitution of the impaired iNKT cell pool and amelioration of their function would be a reasonable rationale for the treatment of cancer. In this chapter, the progress made in the clinical trials of iNKT cell-based immunotherapy is briefly reviewed, and the role of iNKT cells in tumor immunotherapy is highlighted.
Published Version
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