Clinical treatment of Vogt-Koyanagi-Harada syndrome

Abstract

Objective To evaluate the therapeutic effect of corticosteroids and immunosuppressive in Vogt-Koyanagi-Harada (VKH) syndrome.Methods Forty-four patients (88 eyes) diagnosed with VKH syndrome were collected in our hospital from January 2008 to January 2010.According to the severity of disease,all patients were treated with corticosteroids alone or corticosteroids combined with Cyclosporin A and cyclophosphamide systematically and followed up from 12 to 29 months.Visual acuity,dose and side effects of drugs were reviewed.Results According to treatment of corticosteroids and immunosuppressive for more than one year,visual acuity of 14 primary patients was improved significantly; uveitis of 92.9％ were controlled completely.A complete control of uveitis was achieved in 86.7％ and improved vision was seen in 83.3％ of the 30 recurrent patients.The visual acuity was better in the primary patients than the recurrent.Conclusions Intensive and prolonged systemic treatment with corticosteroids is recommended for the primary mild patients of VKH syndrome; but to the primary severe and recurrent cases,the treatment is effective with corticosteroids combined with cyclosporine A and cyclophosphamide early,and the toxic side effects is less. Key words: Vogt-Koyanagi-Harada syndrome; Uveitis; Corticosteroids; Cyclosporine A; Cyclophosphamide