CLINICAL, SUBCLINICAL FEATURES AND THE RISK FACTORS OF GESTATIONAL TROPHOBLASTIC NEOPLASIA AT HUE CENTRAL HOSPITAL

Abstract

Aim: To determine clinical and subclinical features and the risk factors of gestational trophoblastic neoplasia at Hue Central Hospital. Medthods: A cross-sectional study was conducted from 01/2018 -12/2019 in the Obstetrics and Gynecology Deparment of Hue Central Hospital. This study included 54 women who were diagnosed gestational trophoblastic neoplasia (FIGO 2002) and 54 molar pregnancy women monitored and treated in a stable condition. Results: In gestational trophoblastic neoplasia (GTN) group, age group with women who were ≥ 40 was 4.5 times higher at risk factors of GTN (p < 0.05), the history of stillbirth had 5.2 times higher at risk (p < 0.05). History of molar pregnancy accounted for 20.4% with OR = 4.3 (95% CI = 1.2 - 16.3). The risk in the number of births ≥ 3 was 5.1 times higher (p < 0.05). The rate of toxemia in GTN group was 66.7% with OR = 8.6; 95%CI =3.3-21.4 (p < 0.05). The women with hyperthyroidism were 3.1 times higher at risk of GTN. The risk of bilateral theca-lutein cyst in GTN group was 12.6 times more than that of control group. The percentage of beta hCG level > 100.000 mUI/ml before treatment in GTN group was 75.9% with 6.8 times higher at risk of GTN (p < 0.05). Conclusion: A history of molar pregnancy, birth multiple times,a history of stillbirth, presence of hyperthyroidism, the bilateral theca-lutein cyst > 4 weeks, the percentage of beta hCG level > 100.000 mUI/ml before treatment, are risk factors found to be associated with the gestational trophoblastic neoplasia. Key words: Molar pregnancy, gestational trophoblastic neoplasia, risk factors