Clinical study on the treatment of chronic renal failure of spleen and kidney yang deficiency and turbid toxic obstruction type with self-made Huazhuo Baoyuan decoction

Abstract

Objective To observe the effect of treating chronic renal failure with self-made Huazhuo Baoyuan decoction. Methods 90 patients of chronic renal failure belonging to spleen and kidney yang deficiency and turbid toxic obstruction type diagnosed by TCM syndrome differentiation were randomly divided into a treatment group and a control group according to the date of reception. 40 cases in the control group were treated with conventional western medicine, which were low-salt high-quality low-protein diet; to correct acid-base balance and electrolyte imbalance; to correct anemia; adding amino acids; to control blood sugar in patients with history of diabetes; to control blood pressure in patients with hypertension. 50 patients in the treatment group were additionally treated with self-made Huazhuo Baoyuan decoction on the basis of the control group. Such indexes as symptom score, serum creatinine （Scr）, blood urea nitrogen （BUN）, endogenous creatinine clearance rate （Ccr）, hemoglobin （Hb）, liver function： aspartate aminotransferase （AST）, alanine aminotransferase （ALT） ; lipids： total cholesterol（TC）, triglyceride（TG）, high density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol （LDL-C） were observed before and after the treatment. Results After treatment, total effective rate was 88.0% and 67.5% in the treatment group and the control group respectively, the difference was statistically significant （P= 0.012） . The value of Scr （292.95___ 85.95） μmol/L, BUN （22.69±9.84） mmol/L, Ccr （22.69±9.84） ml/min, CH （6.23 ±0.57） mmol/L, TG （1.70±0.22） mmol/L, HDL-C （1.45 ± 0.04） mmol/L, LDL-C （3.30 ± 0.60） mmol/L showed significant difference after the treatment than before in the treatment group （P〈0.05 or P〈 0.01）. Compared with the control group of after treatment[Scr（336.63 ± 90.77）μmol/L, BUN（10.47 ± 2.71） retool/L, Ccr（19.47 ±6.71） ml/min, CH （7.21 ± 0.62） retool/L, TG （2.30 ± 0.27） mmol/L, HDL-C （0.87 ±0.05） mmol/L, LDL-C （5.60±0.70） retool/L], the difference was statistically significant （P〈0.05）. Conclusion Self-made Huazhuo Baoyuan decoction was effective and safe to treat chronic renal failure. Key words: Traditional Chinese medicine; Renal failure; Chronic