Abstract
This study investigates the correlation between the gene polymorphism of rs8192675 (C/C) locus of SLC2A2 in patients with type 2 diabetes (T2DM) and the efficacy of metformin. For this purpose, we have selected 110 T2DM patients (T2DM group) and 110 healthy people (control group) who were treated in our hospital from January 2019 to January 2020 as the research subjects. PCR-restriction fragment length polymorphism (PCR-RFLP) method detects the distribution frequency of gene polymorphism. The patients in the T2DM group were treated with metformin and followed up for 90 days to analyze the relationship between the efficacy of metformin and the SLC2A2 gene polymorphism. The genotypes of SLC2A2 rs8192675 in the control group and in the T2DM group conformed to the Hardy–Weinberg equilibrium law. Compared with the control group, the CT type and the CC type at rs8192675 in the T2DM group were significantly higher (P < 0.05). For rs8192675, there was no significant difference in TT, CT, CC FPG, 2hPBG, and HbA1c levels before treatment (P > 0.05); after metformin treatment, the reduction in FPG, 2hPBG, and HbA1c in CC patients was lower than that of TT and CT patients (P < 0.05). SLC2A2 gene polymorphism site rs8192675 CC type T2DM patients are sensitive to metformin and have a better hypoglycemic effect.
Highlights
Diabetes mellitus is a group of metabolic diseases characterized by increased chronic blood sugar levels, which are caused by defects in insulin secretion and/or function
We have selected 110 type 2 diabetes mellitus (T2DM) patients (T2DM group) and 110 healthy people who were treated in our hospital from January 2019 to January 2020 as the research subjects
PCR-restriction fragment length polymorphism (PCR-RFLP) method detects the distribution frequency of gene polymorphism. e patients in the T2DM group were treated with metformin and followed up for 90 days to analyze the relationship between the efficacy of metformin and the SLC2A2 gene polymorphism
Summary
Diabetes mellitus is a group of metabolic diseases characterized by increased chronic blood sugar levels, which are caused by defects in insulin secretion and/or function. Due to long-term carbohydrate, fat, and protein metabolism disorders, multiple systems of the body are damaged, which can eventually lead to chronic progressive disease, hypofunction, and failure of various tissues and organs, which seriously affect the quality of life of patients, reduce the life span of patients, and increase the mortality rate of patients. Among the rapidly growing diabetic patients, type 2 diabetes mellitus (T2DM) patients account for the vast majority. It is believed that insulin resistance and insulin secretion defects are the basis of their onset, which can occur at any age, more often than 35-year-old adult. T2DM is caused by a combination of multiple factors, including genetic and environmental factors. Insulin gene , KCNJ11, TCF7L2, SLC30A8 proliferator receptor gene [2,3,4,5,6], etc., are all related to the polymorphism of T2DM-related genes
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