Clinical study on the changes of intestinal flora and probiotic treatment of those afloat navy personnel with hyperlipidemia

Abstract

Objective To investigate the changes of intestinal flora and effects of probiotic treatment on those afloat navy personnel with hyperlipidemia. Methods (1)Analyses of intestinal flora were made in 78 patients with hyperlipidemia and 78 healthy volunteers. (2)Those patients with hyperlipidemia were randomly divided into 2 groups: the lipitor therapy group and the lipitor + probiotic therapy group (or the combined therapy group). Levels of serum trigeminal ganglion (TG) and total cholesterol (TC) were detected both before therapy and 15 and 30 days after therapy, and analysis of fecal microbial population was made at day 30 after therapy. Results (1)There existed imbalance of intestinal flora in patients with hyperlipidemia, with the manifestations of significant decrease in anaerobic bacteria (Lactobacillus acidophilus, Bifidobacterium, Enterococcus) and obvious increase in aerobic bacteria (E. coli) (P<0.05). (2)At day 15, the levels of the serum TG and TC in the combined therapy group[(1.50±0.30)mmol/L and(5.60±0.88)mmol/L] decreased significantly (P<0.05), which was earlier than that of the Lipitor therapy group and the patient's intestinal flora was improved. Conclusions There existed an imbalance of intestinal flora in the patients with hyperlipidemia. Research results indicated that the imbalance of intestinal microecology was probably involved in the occurrence and development of hyperlipidemia. Treatment with probiotics and lipitor could quickly reduce the level of serum TG and TC and help to adjust intestinal flora imbalance. Key words: Intestinal flora; Hyperlipidemia; Probiotics; Afloat navy personnel