Abstract
Objective To investigate the effect of carvedilol in the treatment of dilated cardiomyopathy with the appropriate dose.Methods 35 cases of dilated cardiomyopathy with heart failure were selected and used target heart rate (THR) as a therapeutic target,patients were divided into treatment group (THR 55 beats/min,n=25) and control group (THR 60 beats/min,n=10).Conventional drug treatment with carvedilol was used.Results After the observation,the outcome measures after treatment in two groups had significantly improved the treatment group,systolic blood pressure,left ventricular ejection fraction,left ventricular end-diastolic diameter,left ventricular end systolic diameter,6MWT and cardiothoracic ratio improved significantly better than the control group (P＜0.05).The two groups achieved a percentage of the drug' s maximum tolerated dose was similar to contrast the two groups with no significant difference (P＜0.05).Conclusion 3 months after the carvediiol treatment in patients with dilated cardiomyopathy heart failure (NYHA functional classification grade Ⅱ ～ Ⅲ) can obtain significant efficacy; carvedilol used in pdilated cardiomyopathy patients with heart failure,it is safe the THR set at 55 times / min or so,and the appropriate dose of 0.8 mg/(kg?d) is recommended. Key words: Dilated cardiomyopathy; Carvedilol; Appropriate dose
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