Clinical study of RT3DE in assessment of the relations between LVEF and contractive synchronism in patients with severe coronary artery disease

Abstract

Objective To study the relations between left ventricular ejection fraction (LVEF) and contractive synchronism in patients with three-vessels coronary artery disease by real-time three-dimensional echocardiography (RT3DE).Methods Forty patients with three-vessel disease coronary artery disease (CAD) and 20 patients without CAD confirmed by selective coronary angiography were choosed.CAD patients were divided into old myocardial infarction group (OMI,n =20) and non-myocardial infarction group(nMI,n =20).The left ventricle end-diastole volume(LVEDV),ejection fraction (LVEF),the 16 segments and those standard deviation (Tmsv16-SD),the maximal difference of time among all 16 segments (Tmsv16-Dif) were measured by RT3DE.Results Compared with control group:LVEDV,Tmsv16-SD and Tmsv16-Dif were significantly increased,LVEF was significantly decreased in CAD patients (P ＜0.01).Compared with nMI group,the same change happened in OMI group (P ＜ 0.05).In CAD patients group,LVEF was negatively correlated with Tmsv16-SD (r =-0.594,P ＜ 0.01)and Tmsv16-Dif (r =-0.498,P ＜ 0.01).Conclusions Left ventricular remodeling is resulted in three-vessel disease.The left ventricular remodeling in OMI outweights nMI.Left ventricular contractive synchronism index can reflect left ventricular systolic function in certain degree. Key words: Coronary artery disease; Real-time three-dimensional echocardiography; Left ventricular; Systolic function; Synchronism