Clinical study of relation and treatment with different platelet formulations between aspirin and relapsing haemorrhage after operation in hypertensive cerebral haemorrhage patients

Abstract

Objective To explore the relation and clinical efficiency for fresh apheresis platelets and frozen apheresis platelets between aspirin and relapsing haemorrhage after operation in hypertensive basal ganglia cerebral haemorrhage patients.Methods 816 patients with hypertensive basal ganglia cerebral haemorrhage were treated with craniotomy.Patients without aspirin medication before the onset of the disease were chosen as the control group(group A).There were 326 cases in group A.The patients used aspirin before the onset of the disease were randomly assigned to three groups(group B,C and D).,The patients in group B were given routine therapy without other intervention.On the basis of routine therapy,the patients in group C were received frozen apheresis platelets,and the patients in group D were received fresh apheresis platelets.Except the patients without satisfactory heamostasis during operation,there were 315 patients in group A,154 patients in group B,160 patients in group C and 160 patients in group D.Results The rate of relapsing heamorrhage after operation,heamatoma volume of relapsing haemorrhage,death rate and ADL score grades by 6 months follow-up survey in four groups showed that there were more significant difference between group A and group B,group B and group C,group B and group D(P 0.05).Condnsion Aspirin can increase the chance of relapsing haemorrhage after operation,disablement rate and death rate in hypertensive basal ganglia cerebral haemorrhage patients.The chance of relapsing haemorrhage after operation.disablement rate and death rate can be decreased after using fresh apheresis platelets and frozen apheresis platelets.There was no significant difierence of curative effect between used fresh apheresis platelets and frozen one.Fresh apheresis platelets should be used as a first-line therapy. Key words: Aspirin; Hypertensive basal ganglia cerebral haemorrhage; Relapsing haemorrhage after operation; Fresh apheresis platelets; Frozen apheresis platelets