CLINICAL STUDY OF PREVALENCE OF HUMAN PAPILLOMA VIRUS (HPV) BY ELISA METHOD IN FEMALES ATTENDING GYNAECOLOGY OPD

Abstract

Background: Women with normal cervical cytology, who are infected with high-risk HPV type, have an approximately 100-fold increased risk of developing cervical cancer compared with uninfected women. Present study was conducted to study seroprevalence of Human Papilloma Virus by ELISA method in female patients attending in Gynecology OPD of in a tertiary care hospital. Present study was cross- Material and Methods: sectional study, observational study, conducted female patients clinically suspected of having HPV infections like bleeding per vagina, irregular menstruation, pain in lower abdomen or post-coital bleeding or had any abnormal ndings on per vaginal examination. Among 160 Results: patients, majority of were from age group 31-40 years (39.38%), married (88.75 %), married at 18-20 years age (54.36 %), had parity of 2-4 (83.75%). All females had gynecological problems followed by women who were smoker ( 33.13 %), suffering from STD's (29.37 %), had alcohol drinking habit (25 %), had multiple sexual partner (5 %) and family history of cervical cancer (2.5 %). The patients who used homemade napkins had a highest seroprevalence of HPV 68.18% followed by patients who are suffering from STD's (63.83 %), had a family history of cervical cancer (50 %), women who used to smoke (37.7 %), drink (25 %), had multiple sex partners (25 %) and the least number seropositivity was among patient who had gynecological problems 23.12%. The sero-prevalence among patients for HPV was 23.12%. Conclusion: The prevalence increased with early marriages, high parity, and middle socio-economic status group. So, our study will guide for planning and implementation of governmental HPV infection control measures and the consequences of infection around the world. ELISA method is an important diagnostic method in future in HPV infection detection as it has several advantages over other existing diagnostic methods in respect of early detection, reliability, cost effectiveness and patients compliance as blood can be easily accessible.