STUDY OF HUMAN PAPILLOMA VIRUS (HPV) & PAP SMEAR IN CLINICALLY SUSPECTED CASES OF HPV IN A TERTIARY CARE HOSPITAL IN MUMBAI

Abstract

Background: Cervical cancer is the commonest cancer amongst Indian women and the second most common cancer in the women worldwide. Persistent infection with high-risk HPV (HR-HPV) is the most important risk factor for cervical cancer precursors and invasive cervical cancer. Present study was conducted to study prevalence of Human Papilloma Virus (HPV) & correlation of PAP smear in clinically suspected cases of HPV. Present study was prospective, observational study, conducted in female pa Material and Methods: tients clinically suspected of having HPV infections like bleeding per vagina, irregular menstruation, pain in lower abdomen or post-coital bleeding or had any abnormal ndings on per vaginal examination. In the present study, majority of patients were in age group Results: 31-40 years (39.38%), married (88.75%), were married at 18-20 years age (54.36%) & had parity of 2-4 (83.75%). The patients who used homemade napkins had a highest seroprevalence of HPV (68.18 %), followed by patients who are suffering from STD's (63.83%), family history of cervical cancer (50%), women who used to smoke (37.7%). It was observed that serological test and PAP smear was positive among 03 patients with 34 false positive tests. Comparison between ELISA and cytological study showed that ELISA test was better, and nding was statistically signicant; p value <0.001 (p= Fischer Exact test). Conclusion: Out of 160 PAP smears 2.20% were positive. The PAP smear positive patients were also seropositive of HPV by ELISA method