Clinical study of low molecular weight heparin calcium combined with graduated compression stockings in preventing deep venous thrombosis of lower extremity in postoperative patients with gynecological malignant tumors

Abstract

Objective To investigate the effect of low molecular weight heparin calcium combined with graduated compression stockings on preventing deep venous thrombosis of lower extremity in postoperative patients with gynecological malignant tumors. Methods Eighty patients with gynecological malignant tumors in the First People’s Hospital of Pingdingshan from June 2017 to June 2018 were randomly divided into observation group and control group, with 40 cases in each group. The serological indexes, APTT, PT, peripheral diameter of lower extremity, blood flow rate and the incidence of complications were compared between the two groups 5 days after surgery. Results At the 5th day after the operation, the levels of fibrinogen and D-dimer in the observation group were lower than those of the the control group, and the differences between the two groups were all significant (P<0.01); the levels of APTT and PT were higher than those of the control group, and the differences between the two groups were all significant (P<0.01). At the 5th day after the operation, the lower limb circumference and blood flow velocity in the observation group were (21.84±1.82) cm and (0.98±0.24) m/s, which were better than those of the control group [(25.73±1.67)cm、(0.61±0.05)m/s], and the differences were all significant (P all<0.01). The incidence of deep venous thrombosis of lower extremity was 5.0% (2/40) in the observation group and 22.5% (9/40) in the control group, there was significant difference (χ2=5.38, P<0.05). The incidence of complication was 5.0% (2/40) in the observation group and 27.5% (11/40) in the control group, there was significant difference(χ2=7.54, P<0.05). Conclusions Low molecular weight heparin calcium combined with graduated compression stockings can effectively improve the blood flow and prevent deep venous thrombosis in postoperative patients with gynecological malignant tumors. Key words: Low molecular weight heparin; Gynecologic oncology; Deep venous thrombosis