Clinical study of early hyperbaric oxygen therapy for cerebral resuscitation

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Objective To observe effect of early hyperbaric oxygen (HBO) therapy on cerebral resuscitation and to provide good evidence and method for treatment of cerebral resuscitation.Methods The patients responded to cardiac pulmonary resuscitation (CPR) were divided into 2 groups,the early HBO group( within one week of onset) and delayed HBO group (after 1 week of onset).All patients were given routine medicinal treatment coupled with HBO therapy.The exposure pressure of HBO and course of treatment were all same,only time point of HBO intervention was different.Evaluation was made by using the Revised 2001 PVS Criteria for Diagnosis and Treatment ( Nanjing Criteria).Consciousness of patients was evaluated both before HBO therapy and 6 months after onset.Results Of 18 patients who received early HBO therapy,4 patients recovered and returned to normal life (effective),5 patients became fully conscious,but with minor disability (effective),and 9 patients became vegetable (ineffective),with a total effective rate of 50.0％.Of 53 patients with delayed HBO therapy,9 patients recovered and returned to normal life (effective),15 patients became fully conscious,but with minor disability (effective),and 29 patients became vegetable (ineffective),with a total effective rate of 45.3％.No significant differences could be seen in effective rates between 2 groups (P ＞0.05).However,statistical significance could be noted,when effective rates of 2 groups were compared with those presented in domestic and international reports (2％-10％ ) ( P ＜ 0.05 ).Conclusions In-time HBO therapy could improve prognosis of some patients following cardiac resuscitation,protect neural cells,and improve intelligence of patients,however,early and ultra-early HBO therapy could not increase effective rate of cerebral resuscitation. Key words: Cardiac pulmonary resuscitation; Hyperbaric oxygen; Cerebral resuscitation