Clinical significance of the detection of myocardial enzymes and high sensitive C-reactive protein in chil-dren with herpangina

Abstract

Objective To evaluate the clinical significance of myocardial enzymes and high sensitive C-reactive protein（ hs-CRP） in children with herpangina. Methods A total of 80 children with herpangina（ obser-vation group,n=80）,at the same time,50 healthy children as control group（n=50）were assigned for the detec-tion of myocardial enzymes（AST,LDH,CK,CK-MB）and hs-CRP. Results The elevated CRP levels were found in 45（56. 25%）patients of observation group and 2（4%）patients of the control group,showing statistical significance（χ2 =31. 55,P〈0. 01）. Abnormal myocardial enzyme levels were observed in 59（73. 75%）cases, which included AST 51. 6%, CK 40. 1%, CK-MB 21. 4%, LDH 72. 2%. Abnormal myocardial enzyme levels were observed in 6（12%） cases of control group,which included AST l6%,CK 10%,CK-MB 4% and LDH 12%. The significant differences were observed between the two groups （ P〈0. 01 ） . Conclusion Herpangina children may have different degrees of myocardial damage. Myocardial enzymes and hs-CRP are useful indicators for myocardial injury which may effectively provide reference for clinical diagnosis and treatment. Key words: Herpangina; Myocardial enzymes; High sensitivity C-reactive protein; Myocardial injury