Myocardial enzymes and hypersensitive C-reactive protein in diagnosis of hand-foot-mouth disease

Abstract

Objective To investigate the significance of combined detection of myocardial enzymes and hypersensitive C-reactive protein (hs-CRP) in the clinical diagnosis of hand-foot-mouth disease (HFMD). Methods Children with HFMD clinically admitted into our hospital from January, 2016 to March, 2018 were selected as an observation group. Among them, 30 patients were in the severe group and 80 in the mild group. 80 children taking healthy physical examination in the same period were selected as a control group. The two groups’ myocardial enzymes and high-sensitivity C-reactive protein were detected, and the test results were statistically analyzed. Results The serum aspartate aminotransferase (AST), creatine kinase (CK) activity, creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) activity, alpha hydroxy butyric acid dehydrogenase activity (α-HBDH), and hs-crp concentration were (38.1 ±1.3) U/L, (132.7±7.3) U/L, (30.3±3.3) U/L, (268.4 ±2.7) U/L, (266.5±50.2) U/L, and (10.8 ± 2.4) mg/L in the severe group, respectively; which were significantly higher than those in the mild disease group and the control group, with statistical differences (P<0.05). The CK activity, CK-MB activity, and hs-crp concentration were higher in the mild group than in the control group, with statistical differences (P<0.05). Conclusion The combined detection of myocardial enzymes and high-sensitivity C-reactive protein is sensitive for early detection of hand-foot-mouth disease, and has important clinical value for clinical diagnosis and treatment and detection of prognosis. Key words: Myocardial enzymes; High-sensitivity C-reactive protein; Hand-foot-mouth disease; Clinical significance