Clinical significance of serum CA199 and CEA combination detection in early diagnosis of colorectal cancer

Abstract

Objective To investigate the clinical significance of combined detection of serum carbohydrate antigen 199 (CA199) and carcinoembryonic antigen (CEA) in the early diagnosis of colorectal cancer. Methods The clinical data of 76 patients with colorectal cancer were collected. The levels of CEA and CA199 in serum of 76 patients with colorectal cancer were examined by chemiluminescence method; the diagnostic sensitivity, specificity and detection rates in the diagosis of colorectal cancer were compared between the CEA or CA199 alone method and the double indexes combination detection method; detection levels of CEA and CA199 in patients in different phases of colorectal cancer were compared; detection levels of CEA and CA199 in patients with intraepithelial neoplasia, carcinoma in situ and invasive carcinoma were compared. Results Compared with CEA and CA199 alone method, the sensitivity and detection rate of CEA and CA199 combination method were significantly higher (P 0.05). The detection rate of CEA alone method was significantly higher than that of CA199 alone method, and the difference was significant (P 0.05). However, there was a significant difference in CA199 level between patients with stage Ⅰ, Ⅱ, Ⅲ and Ⅳ colorectal cancer (P>0.05). The level of CA199 has linear correlation with the stage of cancer. There was no significant difference in CEA levels among patients with intraepithelial neoplasia, carcinoma in situ or invasive carcinoma (P>0.05), but there were significant differences in CA199 levels among patients with intraepithelial neoplasia, carcinoma in situ or invasion of cancer, and level of CA199 in patients with intraepithelial neoplasia was in the normal range. Conclusions Combined detection of tumor markers CEA and CA199 has higher detection rate and better sensitivity than single detection method, level of CA199 marker is related to tumor progression in a certain degree, CEA can even make response in the stage of tumor atypical hyperplasia, so the combination of the two markers of colorectal cancer has significance in early monitoring and early diagnosis of colorectal cancer, which is worthy of clinical promotion and reference. Key words: Carbohydrate antigen 199; Carcinoembryonic antigen; Combined detection; Colorectal cancer; Diagnosis