Value of combined detection of serum CEA, CA125 and HE4 in the diagnosis of ovarian cancer

Abstract

Objective To analyze the value of combined detection of human epididymis protein 4 (HE4), carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125), in the diagnosis of ovarian cancer. Methods Sixty patients with ovarian cancer treated in Datong Traditional Chinese Medicine Hospital from January 2016 to January 2019 were selected as ovarian cancer group. Another 60 persons who underwent physical examination in the same period were selected as the healthy examination group. The levels of HE4, CEA, CA125 were detected and compared between the two groups. Results The levels of HE4, CEA and CA125 in the ovarian cancer group were significantly higher than those in the healthy examination group (P<0.05). The diagnostic sensitivity and accuracy of combination of HE4, CEA and CA125 were higher than the individual indicator in diagnosis (P<0.05). The levels of HE4, CEA and CA125 in patients with ovarian cancer were significantly decreased 1 month after operation (P<0.05). In the ovarian cancer group after 6 months of follow-up, the levels of HE4, CEA and CA125 in patients with recurrence were significantly higher than those in the patients without recurrence (P<0.05). Conclusions HE4, CEA and CA125 have higher sensitivity and accuracy in the diagnosis of ovarian cancer, and have higher value in assessing treatment effect and recurrence of the disease. Key words: Ovarian neoplasms; Carcinoembryonic antigen; Carbohydrate antigen 125; Human epididymis protein 4