Clinical significance of plasma D-dimer level detection in patients with non-small cell lung cancer

Abstract

Objective To investigate the clinical significance of plasma D-dimer level detection in patients with non-small cell lung cancer(NSCLC). Methods The plasma D-dimer levels of 58 NSCLC patients and 19 healthy controls were detected by immunol-nephelometry.The relationship between plasma D-dimer level and the pathological type,clinical stage of NSCLC patients were analyzed.Results The plasma D-dimer level of NSCLC patients [(2.40±2.07)μg/ml]were significantly higher, compared with the control group[(0.28±0.09)μg/ml],P＜0.01, and the plasma D-dimer level had positive correlation with clinical stage of NSCLC,but had no relation with sex,hemoptysis and pathological type. Conclusions The D-dimer levels of NSCLC patients are higher,and increases in accordance with severity of the disease,which indicated that NSCLC patients have hypercoagulable state.So the plasma D-dimer levels can be useful for evaluating severity of NSCLC. Key words: Non-small cell lung cancer ; D-dimer ; Hypercoagulable state ;