Abstract
Objective To investigate the changes of procalcitonin (PCT) in patients after liver transplantation and explore their significance for diagnosis and differential diagnosis among bacterial infection, viral infection and acute rejection.Methods PCT was measured in serum of 25 liver trans-plant patients by immunofluorescence sandwich method and the patients were divided into the non-complication group, viral infection group, acute rejection group and bacterial infection group.Results The concentrations of PCT in the 1st, 2nd and 3rd day after transplantation were(24.50 ± 4.6)ng/ml, (21.40± 3.3)ng/ml and (12.25 ± 3.1)ng/ml, respectively and they presented a decreasing tendency.The concentrations of PCT in non-complication group, viral infection group and acute rejection group decreased gradually and were near the normal level of (0.51±0.11) ng/ml after 7～10 days.Moreo-ver, the concentrations of PCT in viral infection group and acute rejection group were (0.44 ± 0.16)ng/ml and(0.53±0.14)ng/ml when the patients were in fever.The concentration of PCT in the viral infection group were(15.70±5.1)ng/ml, which was significantly higher than that in other 3 groups (P 0.05).Conclusion The concentration of PCT in serum is high in the 1st, 2nd and 3rd day then decreased gradually soon.The concentration of PCT is not high in viral infection or acute rejection while significantly high in bacterial infection, so it can be used to differentiate the bacterial infection from acute rejection and virus infection after liver transplantation. Key words: Liver transplantation; Procalcitonin; Bacterial infection
Published Version
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