Clinical Significance of Determination of Serum CoX-2,IL-8 and GM-CSF Levels in Pediatric Patients with Bronchial Asthma

Abstract

Objective To explore the changes of serum COX-2,IL-8 and GM-CSF levels in asthmatic children and their clinical significance.Methods The serum COX-2,IL-8 and GM-CSF levels of 86 asthmatic children,including 42 cases in the acute attack group and 44 cases in the remission group,and 40 healthy controls were detected by sandwich ELISA.Results The serum COX-2,IL-8 and GM-CSF levels in the asthmatic group significantly increased(P＜0.05).The serum COX-2,IL-8 and GM-CSF levels in the acute attack group were higher than those in the remission group(P＜0.05);the serum COX-2,IL-8 and GM-CSF levels in both acute attack group and remission group were higher than those in control group(P＜0.05).Conclusions These cytokines participated in the pathogenesis of bronchial asthma.Monitoring the changes of their serurm levels was helpful for the management of the diseaSes. Key words: Asthma; cyclooxygenase-2; Interleukin-8; Granulocyte-macrophage colony stimulating factor(GM-CSF); Child