Clinical significance of cystatin C in coronary artery disease risk evaluation

Abstract

Objective To evaluate the role of cystatin c in the risk judgement of coronary artery disease. Methods 77 patients with coronary artery disease were involved in the study.They were divided into two groups:Group 1 were patients with angiographically diagnosed coronary artery disease(CAD) with their first acute coronary syndrome(n= 55);Group 2 were patients who had clinically diagnosed coronary disease but were negative on angiography(n= 22).Serum Cys C levels in the two groups and the correlation to CAD were analyzed. Results Serum Cys C levels in patients of Group 1 were higher than that of Group 2[(1.23±1.07) mg/L vs.(0.71±0.32)mg/L,P= 0.002],but no significant difference was found between the two groups in crea levels[(123.76±80.44)μmmol/L vs.(117.63±65.43)μmmol/L,P= 0.230].A ROC analysis revealed that there was a significantly higher risk of ACS above a cystatin c level of 0.875mg/m L(sensitivity:84.3%,specificity:38.8%).A similar analysis carried out for eGFR did not find any significant cut-off points above which risk of ACS was higher. Conclusion The data showed that a high level of cystatin c level is a risk factor for ACS.This could play an important role in the early diagnosis and prevention of adverse cardiovascular events. Key words: Cystatin C; Coronary Artery Disease; Acute Coronary Syndrome; ROC Curve