Clinical significance and changes on serum levels of α-MSH, TNF-α, PCT in patients with acute pancreatitis

Abstract

Objective To investigate the dynamic changes in peripheral blood of patients with acute pancreatitis α-MSH, TNF-α, PCTS and the value of the patient assessment of disease severity. Methods Emergency surgery in the Second Affiliated Hospital of Anhui Medical University from March 2011 to March 2014 were treated 68 cases of acute pancreatitis patients, 36 patients with mild, 32 cases of severe group. All patients were extracted 1, 3, 5, 7 days after admission blood, and α-MSH was measured by enzyme-linked immunosorbent assay, the content of TNF-αand PCT. Results Compared with the mild group, the serum of patients with severe group of α-MSH concentrations were lower (P <0.05) , while serum TNF-α and PCT levels higher than the mild group (P <0.05) ; in disease severity assessment, α-MSH sensitivity of 82.35% and a specificity of 88.24%, the accuracy was 87.5%, TNF-α sensitivity of 76.47% and a specificity of 82.35%, the accuracy was 81.25%, PCT sensitivity of 70.59% and a specificity of 76.47%, 75.00% accuracy, PCT + TNF-α+ α-MSH sensitivity of 88.24% and a specificity of 94.12%, 93.75% accuracy; area under the PCT, TNF-α, α-MSH and the combination of the three curves 0.690, 0.696, 0.768 and 0.885, respectively. Conclusions Serum α-MSH, monitoring TNF-α, PCT levels have some clinical value in patients with acute pancreatitis disease severity assessment, including α-MSH in the condition assessment of the sensitivity, specificity and positive predictive value were higher than the latter two, and peripheral α-MSH in patients with a low level indicates a serious condition, poor prognosis; addition, combined detection with higher clinical value in the assessment of disease severity. Key words: α-MSH; TNF-α; PCT; Acute pancreatitis