CLINICAL SCORING OF DEPRESSION INDUCED ENDOCRINE MODULATION IS A RISK FACTOR FOR LOW BONE MINERAL DENSITY IN EARLY AGE EFFECTS ON RENAL FAILURE IN SENILE AGE GROUP.

Abstract

Background: Osteoporosis is a multifactorial and slowly emerging global health problem. One out of three women between age group of 50-60 years in India suffers from osteoporosis.Indian women have an early age of onset of osteoporosis as compared to western counterparts.We propose that depression induces early bone loss in majorly premenopausal women and also young age men primarily via specic endocrine mechanisms associated poor lifestyle habits contributory effects on renal failure in senile age group. Aim and Objectives: Ÿ To nd out a new risk factor of secondary osteoporosis in different age group. Ÿ To nd the clinical correlation between depression, serum cortisol, vitamin D, hypothyroidism,creatinine, eGFR and BMD in different age group of both the gender . Ÿ To determine the relationship of decreased renal function with BMD and fracture risk and the role of depression therein. Methods: The study group consisted of 210 osteoporotic patient's age range between 30-75years.The state of depression was analyzed by using Ham D scale. BMD and endocrine parameters was measured by DEXA and chemiluminisence, ELISA. Statistical correlation analyzed by SPSS 22 software. Results: A highly signicant (P <0.00001) correlation was observed between HAM-D score and serum cortisol. The correlation between HAM-D and BMD was also signicant (P <0.05). No signicant correlation was found between BMD and serum cortisol (P฀ 0.05).The correlation of serum vitamin D with BMD was far more signicant (P<0.00001) compared to the association with TSH (P<0.0001).The statistical signicance of creatinine value is far more signicant as compaire to eGFR according to age. A high score of depression associated Summary: with low vitamin D level or high serum cortisol and TSH level which is a risk factor for low BMD in early stage of men and women to develop secondary osteoporosis associated with renal dysfunction by altering eGFR value. It can be concluded that Irrespective of the specic causes, subjects with depression should be considered for screening for bone mineral density and, vice versa, subjects with low BMD should be considered for screening for depression in early stage of life and supplementation of vitamin D with regular physical activity in early stage of life for prevention of secondary osteoporosis associated with renal failure in senile stage.