Abstract
To observe efficacy and side effects, as well as the impact on quality of life, of Kanglaite® (Coix Seed Oil) injections combined with chemotherapy in the treatment of advanced gastric cancer patiensts. A consecutive cohort of 60 patients were divided into two groups:the experimental group receiving Kanglaite® Injection combined with chemotherapy and the control group with chemotherapy alone. After more than two courses of treatment, efficacy, quality of life and side effects were evaluated. The response rate and KPS score of experimental group were significantly improved as compared with those of the control group(P<0.05). In addition, gastrointestinal reactions and bone marrow suppression were significantly lower than in the control group(P<0.05). Kanglaite® Injection enhanced efficacy and reduced the side effects of chemotherapy, improving quality of life of gastric cancer patients; use of Kanglaite® injections deserves to be further investigated in randomized control clinical trails.
Highlights
Gastric cancer is one of the most frequent cancers in the world
A consecutive cohort of 60 patients were divided into two groups: the experimental group receiving Kanglaite® Injection combined with chemotherapy and the control group with chemotherapy alone
Another aim of this study is to evaluate toxicities of Kanglaite® when combined with chemotherapy
Summary
Gastric cancer is one of the most frequent cancers in the world. The highest incidence and mortality rate are in Eastern Asia (Jemal et al, 2011). Chemotherapy is one of the treatment options available in advanced gastric cancer. Kanglaite® (Coix Seed Oil) Injection, which had been confirmed with anti-tumor activity, is one of Chinese herb Preparations that is developed and manufactured by Zhejiang Kanglaite Pharmaceutical Co., Ltd in China (Li 2005). It is mainly used for the treatment of no-small cell lung cancer, liver cancer, gastric cancer etc (Lian et al, 2006; Zhu et al, 2009). We hypothesize that it is effective when applied with chemotherapy in the treatment of gastric cancer Another aim of this study is to evaluate toxicities of Kanglaite® when combined with chemotherapy
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