Abstract
To assess the efficacy, side effects, and the impact on quality of life with Qinin® (Cantharidin sodium) injection combined with chemotherapy for gastric cancer patients. A consecutive cohort of 70 patients were divided into two groups: experimental group with cantharidin sodium injection combined with chemotherapy, while the control group received chemotherapy alone. After more than two courses of treatment, efficacy, quality of life and side effects were evaluated. The response rate of experimental group was not significantly different from that of the control group (P>0.05), but differences were significant in clinical benefit response and KPS score. In addition, gastrointestinal reactions and the incidence of leukopenia were lower than in the control group (P<0.05). Qinin® (Cantharidin sodium) injection combined with chemotherapy enhances clinical benefit response, improving quality of life of gastric cancer patients and reducing side effects of chemotherapy. Thus Qinin® (Cantharidin sodium) injection deserves to be further investigated in randomized control clinical trails.
Highlights
Based on the GLOBOCAN 2008 estimates, stomach cancer is the third most common cause of death from cancer in males and the forth in females,with 989,600 new cancer cases and 738,000 deaths in this year (Jemal et al, 2011)
A consecutive cohort of 70 patients were divided into two groups: experimental group with cantharidin sodium injection combined with chemotherapy, while the control group received chemotherapy alone
*N, number cases; CR, Complete Remission; partial response (PR), Partial response; SD, stable disease; PD, progressive disease; *Experimental group was chemotherapy combined with cantharidin sodium injection.which is developed and manufactured by Guizhou magic Pharmaceutical Co., Ltd in China
Summary
Based on the GLOBOCAN 2008 estimates, stomach cancer is the third most common cause of death from cancer in males and the forth in females,with 989,600 new cancer cases and 738,000 deaths in this year (Jemal et al, 2011). Stomach cancer has become the common and frequently-occurring disease which seriously hazard to human health (Ferlay et al, 2010). Chemotherapy is one of important treatment of gastric cancer and is the only treatment option available in advanced gastric cancer. Qinin® (Cantharidin sodium) injection, which is Semisynthetic derivative of cantharidin, has been developed and manufactured by Guizhou magic Pharmaceutical Co., Ltd in China, Cantharidinate sodium Injection is one of Chinese herbal preparation with anti-cancer activity, which mainly used for the treatment of solid tumor including gastric cancer (Cui et al, 2008; Guo et al, 2009; Liang et al, 2011). Our hypothesis is that the combination of Chemotherapy and Canthar-idinate sodium Injection could be superior to Chemotherapy alone in treatment efficacy and toxicity regarding gastric cancer
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