Clinical research of Yangxue-Qingnao granules on posterior circulation of ischemia

Abstract

Objective To evaluate the curative effect and security of Yangxue-Qingnao granules on posterior circulation ischemia. Methods 52 patients with posterior circulation ischemia from September 2012 to January 2014 in Remin hospital of Wuhan Universityk, were randomly recruited into a control group and a treatment group, with 26 cases in each group. The control group was only treated with flunarizine HCL and Betahistine Mesilate Tablets, while the treatment group was given Yangxue-Qingnao granules based on the control group. The change of clinical symptoms, TCD and cervical vascular ultrasound were observed before and after the treatment. Results After the treatment, the total effective rate of treatment group was significantly different to the control group (96.2% vs. 76.9%; χ2=4.127, P=0.042). The changes of blood flow velocity of vertebral artery, basilar artery and posterior inferior cerebellar artery were all decreased after the treatment in both groups ( t value in the treatment group were 20.624, 13.773, and 9.485 respectively，t value in the control group were 13.203, 9.550, and 5.655, respectively, all P<0.01）, besides such decreases in the treatment group were better than the control group (all P<0.01）. After the treatment, the condition of carotid IMT decrease was significantly better in the treatment group than the control group (the number rate of IMT decrease was (96.2% vs. 69.2%; χ2=5.318, P=0.021). Conclusion Yangxue-Qingnao granules can obviously improve the blood flow velocity and the thickness of IMT in patients with posterior circulation ischemia. The short-term curative effect is obvious. Key words: Brain ischemia; Vertebrobasilar insufficiency; Yangxue-Qingnao granules