Clinical research of outpatient treatment for patients with stable chronic obstructive pulmonary disease

Abstract

Objective To research different treatment for patients with stable chronic obstructive pulmonary disease （COPD）. Methods The 90 patients were divided into three groups： shulidie group （inhaled salmeterol （50 μg） fluticasone （250μg） twice daily,drug combination group [raked theophylline retard tablets （0.1 g） by mouth and inhaled fluticasone （125 μg） twice daily] and control group（inhaled salbutamol in need）. Pulmonary function （ FEV1 , FVC, FEV1 % predicted, FEV1/FVC and FEF25 75 % ）, 6 minute walking distance and the exacerbations were observed during the 1 year treatment period. Results Both shulidie and drug combination groups resulted in improvements in pulmonary function （FEV1, FVC,FEV1 predicted,FEV1/FVC and FEF25-75%） and 6 minute walking distance at the end of the 1 year treatment period when compared with control group or baseline（all P 〈0.05）. Shulidie group improved the FEF25 75% and FVC value to a greater extent than control group （2.41±0.61 and 2.11 ±0.47,44.9±10.1 and 35. 4 ±8. 8, respectively, both P 〈0.05）.Conclusions The shulidie （50/250 μg） and combination drug （theophylline retard tablet and fluticasone aerosol） have effect for patients with stable COPD. The former has stronger effect to improve FVC and FEF25-75% than latter. Key words: Chronic obstructive pulmonary disease; Salmeterol fluticasone; Fluticasone aerosol; Theophylllne retard tablet ; Pulmonary function