Abstract
Objective To study the muscular relaxant effect of doses of cisatracurium in infants and young children under combined intravenous-inhalational anesthesia, in order to optimize the dosage of cisatracurium. Methods This study enrolled one hundred infants and young children elected for operation under combined intravenous-inhalational anesthesia in our hospital. These cases were divided into group A(3-6 months old) and group B(7-36 months old). Subjects in group A and group B were further divided into two subgroups receiving either 0.10 mg/kg or 0.15 mg/kg cisatracurium. Each subgroup had 25 cases. The muscular relaxant effect was evaluated by analyzing its onset time, clinical reaction time, recovery index(RI), twich(Th) time and train-of-four(TOF) recovery time. Results The onset time of muscle relax in group A was significantly shorter than in group B(P 0.05). Conclusions The age of infants and young children and the loading doses of cisatracurium was the key factors to determine the muscular relaxant effect. Key words: Infants and young children; Combined intravenous and inhalational anesthesia; Muscular relaxant effect; Cisatracurium
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