Abstract
Objective To investigate the effect of sevoflurane intravenous-inhalation combined anesthesia on liver function, renal function, and cellular immune function in surgical patients with hepatitis cirrhosis. Methods 62 surgical patients with hepatitis cirrhosis treated in our hospital from March 2014 to March 2015 were selected and randomly divided into observation group (31 cases) and control group (31 cases). Within 24 hours before surgery, various types of drugs of the two groups disabled, opening the peripheral vein after into the operating room, routine testing of oxygen saturation, blood pressure, electroencephalogram, electrocardiogram, intramuscular injection of phenobarbital sodium and atropine before anesthesia. The observation group was treated with intravenous-inhalation combined anesthesia [anesthesia induction: intravenous injection of fentanyl 3μg, etomidate injection 0.2 mg/kg, midazolam injection 0.05 mg/kg, cis-atracurium 0.2 mg/kg; anesthesia maintenance: inhalation of 3% sevoflurane, continuous injection of paracetamol atracurium 0.2 mg/(kg•h), remifentanil 0.2μg/(kg•h)], while the control group was treated with total intravenous anesthesia [anesthesia induction: propofol 2 mg/kg instead of etomidate, anesthesia maintenance: continuous injection of propofol injection 5 mg/(kg•h) instead of sevoflurane, other narcotic drugs with the observation group]. Compared liver function, renal function, and cellular immune function of two groups before anesthesia (t1), 2 h after induction (t2), 1 d after operation (t3), recorded the adverse reactions that occurred within 24 hours after operation. Results In two groups, the levels of ALT, Scr, and BUN at t2 were significantly higher than those at t1 (P 0.05). Conclusion In the treatment of patients with hepatitis cirrhosis, sevoflurane intravenous-inhalation combined anesthesia mildly affect the liver and renal function, cellular immune function, which is conducive to immune function recovery, safe and reliable, worthy of clinical application. Key words: Sevoflurane; Intravenous-inhalation combined anesthesia; Hepatitis cirrhosis; Liver and renal function; Immune function
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