Abstract
Objective To investigate the clinical effect of modified Danggui-Sini decoction combined with Mecobalamin on diabetic peripheral neuropathy. Methods A total of 104 patients with diabetic peripheral neuropathy from January 2015 -2016 year in December in our hospital patients were randomly divided into study group and control group, each of 52 patients. The control group was given Mecobalamin 0.5 mg/times. The study group was given modified Danggui-Sini decoction plus the intervention of the observation group. Four weeks were a course of treatment. The clinical effect rates, the incidence of adverse events, change of common peroneal nerve conduction velocity, hemorheological indexes and advanced glycation end products (AGEs) were compared between the two groups before and after treatment. Results The total effective rate of the study group was 96.2%, which was significantly higher than 82.7% of the control group (χ2=4.981, P<0.05). During treatment, the incidence of adverse events was 5.8% in the study group, and the incidence of adverse events in the control group was 3.9%. There was no significant difference in the incidence of adverse reactions between two groups (P<0.05). After treatment, the motor nerve conduction velocity (49.1 ± 4.5 m/s vs. 42.8 ± 4.3 m/s) and sensory nerve conduction velocity (40.1 ± 3.7 m/s vs. 36.5 ± 3.9 m/s) in the study group were significantly higher than those in the control group (t=2.732, 2.723, P<0.05). The whole blood viscosity [(3.72 ± 0.58) mPa•s vs. (4.55 ± 0.47) mPa•s], plasma viscosity [(1.03 ± 0.12) mPa•s vs. (1.78 ± 0.09 ) mPa•s], erythrocyte blood pressure (31.23% ± 3.19% vs. 37.33% ± 4.12% ), AGEs (58.44 ± 4.87 ng/L vs. 68.03 ± 4.98 ng/L) in the observation group were significantly lower than those in the control group (t=2.704, -2.682, -2.737, -2.856, P<0.05). Conclusions The modified Danggui-Sini decoction combined with Mecobalamin on diabetic peripheral neuropathy can improve peripheral nerve conduction velocity, improve curative effect, showed fewer adverse events. Key words: Diabetic neuropathies; Dang Gui Si Ni Tang; Mecobalamin; Clinical study
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