Abstract
Objective: To observe the clinical curative effect of Fallopian Tube Recanalization combined with Traditional Chinese Medicine and to explore the mechanism of Traditional Chinese Medicine in the treatment of Tubal Obstructive Infertility. Method: We selected 180 patients with Tubal Obstructive Infertility and randomly divided them into 3 groups, each group contained 60 subjects. The subjects of the first group received treatment of Fallopian Tube Recanalization combined with Traditional Chinese Medicine, the second group received Fallopian Tube Recanalization alone and the third group received Traditional Chinese Medicine alone. Then we observed the success rate of each group according to their Fallopian tube patency rate, pregnancy rate and Fallopian tube re-adhesion formation rate. Result: (1) The success rate of the first group was 81.7%, while that of the second group was 78.3%, and 56.7% for the third group. There was a significant difference between the first group and the third group, as well as the second group and the third group (P<0.05). (2) One year’s follow-up after treatment showed the pregnancy rate (defined as numbers of pregnancy over numbers of successful recanalization procedures) of the first, second and third group were 65.3%, 53.2% and 64.7% respectively. Although there was no significant difference between these 3 groups, the pregnancy rate of the two groups which applied Traditional Chinese Medicine was higher than the group which applied recanalization procedure alone. (3) One year after treatment, there were 5 Fallopian tube re-adhesion cases in the first group, 12 cases in the second group and 5 cases in the third group, the re-adhesion rate was 10.2%, 25.5% and 14.7% respectively. There was a significant difference between the first group and the second group (P<0.05). Conclusion: Interventional Fallopian Tube Recanalization can increase the rate of patency of occluded Fallopian tube, while Traditional Chinese Medicine can decrease post-operational tubal re-adhesion formation rate and facilitate pregnancy. The two treatments can be combined to treat Tubal Obstructive Infertility.
Highlights
Tubal Obstructive Infertility is a common gynecological disease which causes 40-60% of infertility in women [1]
There was no significant difference between these 3 groups, the pregnancy rate of the two groups which applied Traditional Chinese Medicine was higher than the group which applied recanalization procedure alone
Interventional Fallopian Tube Recanalization can increase the rate of patency of occluded Fallopian tube, while Traditional Chinese Medicine can decrease post-operational tubal re-adhesion formation rate and facilitate pregnancy
Summary
Tubal Obstructive Infertility is a common gynecological disease which causes 40-60% of infertility in women [1]. How to open the obstructed Fallopian tube and keep its function and lasting patency is a key research area in clinical gynaecological medicine, and how to improve intrauterine pregnancy rate is the end objective of treating tubal obstructive infertility. We selected randomly some patients with tubal obstructive infertility as research subjects and treated them with Fallopian Tube Recanalization or Traditional Chinese Medicine or the combination of these two, so as to evaluate the curative effects of these treatments. We did relative analysis of the results, and further explored the mechanism of Traditional Chinese Medicine in treating tubal obstructive infertility. All the subjects were selected from the patients who underwent interventional Fallopian Tube Recanalization in the Department of Interventional Radiology of the Second Affiliated Hospital of Baotou Medical College during Jun 2006 - Jun 2012
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