Abstract
ABSTRACT Background: India’s national coronavirus disease 2019 (COVID-19) vaccination program started in January 2021 and prioritized health-care workers (HCWs). This study was conducted to assess vaccine effectiveness among COVID-19-vaccinated HCWs and symptomatology in reverse transcription-polymerase chain reaction (RT-PCR) confirmed COVID-19 among HCWs. Materials and Methods: This cross-sectional study was conducted in a tertiary care medical teaching institute from Uttar Pradesh during the second wave of COVID-19 (from February 2021 to June 2021). All RT-PCR-confirmed COVID-19 HCWs were divided into various groups depending on their vaccination status. The data regarding demographic profile along with vaccination status, the gap between COVID-19 positivity and vaccination, symptoms, hospitalization, time to recovery, and previous history of COVID-19 were recorded. Results: A total of 1685 HCWs vaccinated with the Covishield vaccine from January to March 2021 were inquired. Out of 1685 HCWs, 82 (4.8%) were tested positive by RT-PCR after vaccination. Of 82 positive HCWs, 84% experienced mild symptoms, 12.2% experienced moderate symptoms, and 3.7% experienced severe manifestations leading to hospitalization. Among these positive HCWs, 25.6% recovered within 7 days, 35.3% recovered in 7–10 days, 15.8% recovered in 11–14 days, and 23.1% recovered after 2 weeks from the 1st day of experiencing symptoms. Among nonvaccinated patients, 878 (5.3%) required hospitalization. Conclusion: COVID-19 vaccination by Covishield may not fully prevent from infection by severe acute respiratory syndrome coronavirus 2 or its different variants. Few postvaccination cases may present with severe symptoms and require hospitalization.
Published Version
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