Abstract
Polycystic ovarian syndrome (PCOS) is an endocrine-metabolic disease affecting women in their childbearing age. Although, it has a high prevalence (3-10%), the exact etiology is poorly understood. Insulin resistance (IR) is involved in pathophysiology of PCOS, and some esterase enzymes such as butyrylcholinesterase (BuChE) and paraoxonase 1 (PON1) have been found to be affected in IR disorders. The aim of this study was to investigate serum esterase enzymes and their relationship with IR and clinical presentations PCOS. In this case-control study, 56 PCOS and 62 non-PCOS women were enrolled. Demographic and clinical parameters including working, marital, parity and menstrual status, body mass index (BMI), IR, BuChE and PON1 activity were measured and compared between the groups. The marital and parity status of PCOS women were lower than control group. In comparison with control, PCOS women had significantly higher menstrual irregularity, IR and BuChE activity as well as lower PON1 activity. There was a significant correlation between BuChE activity and BMI in PCOS women. When justified by IR, BuChE activity was still higher in PCOS women than control. The results indicate that serum esterase enzyme can be changed in PCOS and IR is most probably involved in these alterations.
Published Version
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