Abstract
Carbapenemase-producing Enterobacterales (CPE) infections have increased in recent years. Colombia has become an endemic country for this group of microorganisms, and the infections they cause have a serious impact in terms of morbidity and mortality. The early identification of CPE carriers who are admitted to health care centers as patients is necessary to implement adequate isolation and infection control measures to limit the spread of this type of microorganisms in hospitals. Furthermore, treating these infections is a challenging task due to the limited therapeutic alternatives available and the fact that there are only a few studies proving their effectiveness in this setting. Therefore, the objective of the present work is to develop a clinical practice guideline (CPG) for the screening of patients at risk of CPE colonization and the treatment of inpatients with suspected or confirmed infections caused by this type of bacteria through a CPG adaptation process based on the ADAPTE methodology. With this purpose in mind, evidence-informed recommendations for the screening and timely identification of CPE carriers admitted to hospitals are made, as well as for the adequate pharmacological treatment of CPE infections in this context. Taking this into account, the objective of this work is to develop a clinical practice guideline (CPG) for the screening of patients at risk of CPE colonization and for the management of inpatients with suspected or confirmed infections caused by this type of enterobacteriaceae by means of a CPGs adaptation process based on the ADAPTE methodology. With this purpose in mind, evidence-informed recommendations for the screening and timely identification of CPE carriers admitted to hospitals are made, as well as for the adequate pharmacological management of CPE infections in this setting.
Highlights
This article was accepted for publication in V69N3 of Revista de la Facultad de Medicina (Journal of the Faculty of Medicine), considering the concepts of the peer reviewers and the changes made by the authors based on said concepts
It should be noted that this version may differ from the final document since it has not completed the final stages of the editorial process
Guía de práctica clínica para la tamización de pacientes con riesgo de colonización por Enterobacterales productores de carbapenemasas y el manejo de infecciones causadas por estas a. bacterias ad Clinical Practice Guideline for screening of patients with risk of ip colonization by Carbapenemase-producing Enterobacteriaceae tic and managing infections caused by these bacteria n d
Summary
Este artículo fue aprobado para publicación en el v69n3 de la Revista de la Facultad de Medicina teniendo en cuenta los conceptos de los pares evaluadores y los cambios realizados por los autores según estos conceptos. Se publica la versión preliminar del artículo para su consulta y citación provisional, pero debe aclararse que esta puede diferir del documento final, ya que no ha completado las etapas finales del proceso editorial (corrección de estilo, traducción y diagramación) y solo los títulos, datos de autores, palabras clave y resúmenes corresponden a la versión final del artículo. Descargarse y citarse según se indique a continuación, pero debe recordarse que el documento final (PDF, HTML y XML) puede ser diferente.
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