Clinical Population about Diabetes during Pregnancy: A Systematic Literature Review

Abstract

Diabetes during pregnancy, including gestational diabetes mellitus (GDM) and pre-existing diabetes, presents significant challenges to maternal and fetal health. Clinical populations encompass diverse pregnant individuals, each with unique risk factors and outcomes related to diabetes in pregnancy. This systematic literature review aimed to synthesize findings from eligible studies conducted between January 1, 2020, and December 30, 2023, sourced from Web of Science, PubMed, Medline, and the Cochrane Database of literature Reviews, to comprehensively examine diabetes during pregnancy within clinical populations. We followed established systematic review methodologies, including study selection, data extraction, and analysis. Eligible studies underwent rigorous screening to ensure relevance and quality. Data were systematically extracted to identify trends and patterns in epidemiology, risk factors, clinical management, and outcomes. Among the 15 eligible studies, our analysis revealed variations in the prevalence of diabetes during pregnancy across clinical populations, ranging from 5% to 15%. Socioeconomic factors, ethnicity, and maternal age were significant risk factors. Clinical management strategies varied, with insulin therapy predominant in pre-existing diabetes cases (68%) and dietary interventions in GDM (45%). Fetal macrosomia occurred in 18% of cases, while neonatal hypoglycemia affected 14% of infants born to mothers with diabetes. This systematic literature review highlights the multifaceted nature of diabetes during pregnancy in clinical populations. Variations in prevalence and risk factors underscore the importance of tailored healthcare interventions. Diverse management approaches necessitate individualized care plans. The prevalence of adverse outcomes necessitates vigilant monitoring and timely interventions. Our findings inform evidence-based practices research priorities, and support improved care for pregnant individuals with diabetes in clinical populations.