Abstract
To evaluate the association of a diagnosis of lung cancer and combined detection of serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), neuron specific enolase (NSE) as well as the cytokeratin 19 fragment (CYFRA21-1). Serum CEA, CA19-9, NSE and CYFRA21-1 were assessed in 150 patients with lung cancer, 100 patients with benign lung disease and 100 normal control subjects, and differences of expression were compared in each group, and joint effects of these tumor markers in the diagnosis of lung cancer were analyzed. Serum CEA, CA19-9, NSE and CYFRA21-1 in patients with lung cancer were significantly higher than those with benign lung disease and normal controls (p<0.01). It is suggested that these four tumor markers combined together could produce a positive detection rate of 90.2%, significantly higher than that of any single test. Combination detection of CEA, CA19-9, NSE and CYFRA21-1 could significantly improve the sensitivity and specificity in diagnosis of lung cancer, and could be important in early detection.
Highlights
Lung cancer is one of the most common malignant tumors, with high mortality rate worldwide, and still demonstrating a rising trend yearly (Parkin et al, 2005; Liu et al, 2013; Lu et al, 2013)
Serum carcinoembryonic antigen (CEA), carbohydrateantigen 19-9 (CA19-9), neuron specific enolase (NSE) and CYFRA21-1 were assessed in 150 patients with lung cancer, 100 patients with benign lung disease and 100 normal control subjects, and differences of expression were compared in each group, and joint effects of these tumor markers in the diagnosis of lung cancer were analyzed
We developed a method of joint detection of serum carcinoembryonic antigen (CEA), carbohydrateantigen 19-9 (CA19-9), neuron specific enolase (NSE) as well as cytokeratin 19 fragment (CYFRA21-1)
Summary
Lung cancer is one of the most common malignant tumors, with high mortality rate worldwide, and still demonstrating a rising trend yearly (Parkin et al, 2005; Liu et al, 2013; Lu et al, 2013). Conventional disgnositc methods, eg., imaging, fiber bronchoscope, cytology and histopathologic is difficult for early detection of lung cancer (Malik et al, 2013). Tumor markers is suggested to be a usefull tool in this setting, especially in early diagnosis of lung cancer (Buccheri et al, 2002; Schneider et al, 2002; Kav et al, 2012). On this background, we developed a method of joint detection of serum carcinoembryonic antigen (CEA), carbohydrateantigen 19-9 (CA19-9), neuron specific enolase (NSE) as well as cytokeratin 19 fragment (CYFRA21-1). The current study is to test our hypothesis that this method is superior to conventional methods
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