Clinical observation on the effect of deep brain stimulation combined with drug therapy in the treatment of idiopathic Parkinson's disease

Abstract

Objective To study the efficacy and safety of deep brain stimulation (DBS) combined with drug therapy in the treatment of idiopathic Parkinson's disease (PD). Methods From August 2013 to August 2015, 60 patients with idiopathic PD were enrolled. They were divided into DBS group (N = 30) and control group (N = 30) based on different treatment methods. The control group was given routine drug therapy, while DBS group was given DBS combined with drug therapy. Unified Parkinson's Disease Rating Scale (UPDRS) and Parkinson's Disease Quality of Life Scale (PDQUALIF) were used to evaluate the severity of disease and quality of life. Results In comparison with control group, UPDRS suggested lower mind, behavior and mood score ( P = 0.023), lower activities of daily living score ( P = 0.005), lower motor function score ( P = 0.025), lower motor complications score ( P = 0.008) and lower PDQUALIF score ( P = 0.016) in DBS group. In comparison with scores in DBS group before treatment, UPDRS suggested lower mind, behavior and mood score ( P = 0.003), lower activities of daily living score ( P = 0.016), lower motor function score ( P = 0.001), lower motor complications score ( P = 0.016) and lower PDQUALIF score ( P = 0.000) after treatment. Total effective rate was found higher in DBS group [96.67% (29/30); χ 2 = 5.109, P = 0.000] than that in control group [76.67% (23/30)]. Conclusions DBS combined with drug therapy can effectively improve clinical symptoms and quality of life in patients with idiopathic PD. DOI: 10.3969/j.issn.1672-6731.2017.02.007